Christophe Duplais

Current position

CNRS Chargé de Recherche, HDR
Scientific affiliate at the Field Museum of Chicago in the Moreau Lab

Google Scholar
ORCID ID

Phone : +594 594 293 134
email : christophe.duplais chez EcoFoG.gf
Twitter account @chemistophe

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2003-2011 : Organic Chemistry / Organometallic Chemistry / Homogeneous Catalysis / Green Catalysis (M.Sc. ; Ph.D. ; Postdoctorate)

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I studied for 8 years organometallic chemistry, green catalysis and cross-coupling reactions under the supervision of outstanding mentors : undergraduate project in the lab of Paul Knochel (Ludwig Maximilian university of Munich), Ph.D. with Gérard Cahiez (CNRS, Paris), and postdoctoral studies with Bruce Lipshutz (UC Santa Barbara, California).
In Cahiez’s lab I contributed to the field of green chemistry by using non-toxic manganese and iron salts to develop green metal-catalyzed coupling reactions. In Lisphutz’s lab we co-developed with Dr. Arkady Krasovskiy (Dow Chemicals, Michigan) a modification of the nobel prize wining reaction named Negishi cross-coupling, where for the first time this reaction was completed in water at room temperature in a one-pot reaction by using safe and inexpensive surfactants as micelle nano-reactors.

Selected publications :
C. Duplais, A. Krasovskiy, B. H. Lipshutz (2011). Organozinc Chemistry Enabled by Micellar Catalysis. Pd-Catalyzed Cross-Couplings Between Alkyl and Aryl Bromides in Water at Room Temperature, Organometallics, 30, 6090.

C. Duplais, A. J. Forman, B. A Baker, B. H. Lipshutz (2010). UC Pd. A New Form of Pd/C for Sonogashira Couplings. Chem. Eur. J., 16, 3366.

A. Krasovskiy, C. Duplais, B. H. Lipshutz (2009). Zn-Mediated, Pd-Catalyzed Cross-Couplings in Water at Room Temperature Without Prior Formation of Organozinc reagents J. Am. Chem. Soc., 131, 15592.

G. Cahiez, C. Duplais, J. Buendia (2009). Manganese-Catalyzed Oxydative Cross-Couplings of Grignard Reagents Using Oxygen as Oxidant. Angew. Chem. Int. Ed., 48, 6731.

G. Cahiez, A. Moyeux, J. Buendia, C. Duplais (2007). Manganese- or Iron-Catalyzed Homocoupling of Grignard Reagents Using Atmospheric Oxygen as an Oxidant, J. Am. Chem. Soc. 129, 13788.

G. Cahiez, V. Habiak, C. Duplais, A. Moyeux (2007) Iron-Catalyzed Alkylations of Aromatic Grignard Reagents, Angew. Chem. Int. Ed., 46, 4364.

C. Duplais, F. Bures, I. Sapountzis, T. J. Korn, G. Cahiez, P. Knochel (2004). An Efficient Synthesis of Diaryl Ketones by Iron-Catalyzed Arylation of Aroyl Cyanides. Angew. Chem. Int. Ed., 43, 2968.


2012-present : Natural Products Chemistry / Analytical Chemistry / Chemical Ecology / Chemical Biology / Evolution (CNRS Full position)

I am a chemical engineer with a Ph.D. in organic chemistry who studied for 8 years organometallic chemistry, green catalysis and cross-coupling reactions.
In 2012 I joined EcoFoG lab in French Guiana as a CNRS scientist to develop interdisciplinary research studies at the frontier between natural products chemistry, chemical ecology, and analytical chemistry. This has permitted me to gain knowledge in pharmacology, microbiology, parasitology, entomology, molecular biology, ecology and evolution in the context of Amazonian forests. I am co-leading the group Functional Chemodiversity and Applications at EcoFoG with Nadine Amusant (Cirad) and our team includes Yannick Estevez (Research Engineer, CNRS), Emeline Houël (Research Engineer, CNRS) and Cyrielle Sophie (Technician, CNRS).

Currently I am attempting to combine state-of-the-art methods in analytical chemistry (NMR 1D/2D, HR-MAS NMR, TOF-SIMS imaging, MS/MS molecular networking, metabolomics) and molecular ecology (amplicon sequencing, genome mining, transcriptomics) to decipher the biosynthetic pathways of natural products in an evolutionary context.

Our interdisciplinary research in chemistry focuses on three main questions (see the research tab for more information) :
1- What are the chemical markers (and their metabolic pathways) of heartwood formation in tropical trees ?
2- What factors impact biological and chemical interactions between ants and bacteria ?
3- How the biological and chemical diversities of latex impact Amazonian tree evolution ?

Recent publications :
C. Birer, C. Moreau, N. Tysklind, G. Genta-Jouve, L. Zinger*, C. Duplais*. Disentangling the sources of ant cuticular microbiota of two Amazonian ant species sharing a common arboreal nest. In review

T. Fu, D. Touboul, S. Della-Nega, E. Houël, N. Amusant, C. Duplais, G. Fisher*, A. Brunelle* (2018). Tandem MS imaging and in situ identification of bioactive wood metabolites in Amazonian tree species Sextonia rubra. Anal. Chem., 90, 7535–7543.

C. Duplais*, Y. Estevez (2017) Tandem biocatalysis unlocks the challenging de novo production of plant natural products. ChemBioChem, 18, 2192-2195.

C. Birer, N. Tysklind, L. Zinger*, C. Duplais* (2017) Comparative analysis of DNA extraction methods to study the body surface microbiota of insects : a case study with ant cuticular bacteria Molecular Ecology Resources, Early view.

R. Duval*, C. Duplais (2017). Fluorescent natural products as tracers and probes in biology. Nat. Prod. Rep, 34:161-193.

Research

What are the chemical markers of heartwood formation and their biosynthetic pathways in tropical tree species ?🌳🌳

Natural products biosynthesized in the wood transition zone provide a chemical defense against external stresses but they can also influence the physico-mechanical properties of heartwood i.e. hygroscopicity, sweeling, dimensional stability and vibrational behavior. These properties are determinant for woods used in construction, furniture or musical instruments.
We evaluate the chemical diversity of secondary metabolites in sapwood and heartwood of different Amazonian tree species used in construction. We use NMR spectrometry (qNMR, 2D NMR) and MS spectroscopy (TOF-SIMS, metabolomics, molecular networking) on wood to identify main constituents and investigate when possible the biosynthesis pathways of wood metabolites within specific cellular compartments. Correlations between quantitative/qualitative chemical analysis and natural durability bioassays or mechanical properties are tested in order to, in fine, improve statistical models used in agroforestry. Main objectives consist in identifying chemical markers and revealing new insights in wood properties and ecology in oder to assist agroforestry and construction industries to optimize the evaluation of wood forest products.

Collaborators : Jacques Beauchêne (Cirad-EcoFoG, Kourou), Bruno Clair (CNRS-EcoFoG, Kourou), Alain Brunelle & David Touboul (CNRS-ICSN, Gif-sur-Yvette), Grégory Genta-Jouve (COMETE, Université Paris V)
Ph.D. student : Claudiane Flora (Fellowship 2014-2017 : Université de Guyane)
Undergraduate students :
B.Sc : Stéphanie Chou Ket Kime (2015, University of French Guiana)
M.Sc : Gaël Frédéric (2016, University of Strasbourg)
Grant : Labex CEBA

Publications
T. Fu, D. Touboul, S. Della-Nega, E. Houël, N. Amusant, G. Genta-Jouve G. Fisher, A. Brunelle*, C. Duplais*. Biosynthetic investigation of gamma-lactones in Sextonia rubra wood using in situ TOF-SIMS MS/MS imaging to localize and characterize biosynthetic intermediate. In preparation

C. Flora, Y. Estevez, M.-F. Thevenot, C. Duplais*, N. Amusant*. Comparison of near infrared (NIR) and mid infrared (MIR) spectroscopy to study the decay resistance of Amazonian wood species Dicorynia guianensis Amsh. In review.

T. Fu, D. Touboul, S. Della-Nega, E. Houël, N. Amusant, C. Duplais, G. Fisher, A. Brunelle. Tandem MS imaging and in situ identification of bioactive wood metabolites in Amazonian tree species Sextonia rubra. In review.

Bossu J, Beauchêne J, Estevez Y, Duplais C*, Clair B* (2016). New Insights on Wood Dimensional Stability Influenced by Secondary Metabolites : The Case of a Fast-Growing Tropical Species Bagassa guianensis Aubl. PLoS ONE 11(3) : e0150777.


What are the factors impacting the biological and chemical interactions between ants and bacteria ?🐜🐜

We are interested in the biology and the chemistry of bacteria associated ants. We started by isolating cuticular actinobacteria to test their antibiotic activities and we use mass spectrometry molecular networks to explore the diversity of small natural compounds produced when bacteria are co-cultured. We also attempt to better understand acquisition mechanisms, biodiversity, and functions of ant cuticular microbiota by testing correlations between microbiota data (metabarcoding) and chemical data (MS metabolomics).
Currently we study factors that impact the NPRS/KS gene diversity of bacteria associated with ants.

Collaborators : Lucie Zinger (CNRS-EDB, Université de Toulouse), Grégory Genta-Jouve (COMETE, Université Paris V), Alexandre Maciuk & Bruno Figadère (CNRS-BioCIS, Université ParisSud), Niklas Tysklind (INRA-EcoFoG, Kourou), Corrie Moreau (Field Museum of Natural History, Chicago)

Ph.D. student :
Anaïs Chason (Fellowship 2017-2020 : University of French Guiana)
Caroline Birer (Fellowship 2013-2016 : CNRS and CEBA)
Undergraduate students :
M.Sc : Marie-Hélène Soba (2015, Université de Reims Champagne-Ardennes)
B.Sc : Marie-Claire Izeros (2014, Université de Guyane), Sacha Cataldo (2015, Université de Guyane), Franciscar Bien-Aimé (2016, Université de Guyane).
Grant : CNRS Mission pour l’Interdisciplinarité - PEPS EXOMOD (2014-2016)

Publications
C. Birer, C. Moreau, N. Tysklind, G. Genta-Jouve, L. Zinger*, C. Duplais*. Disentangling the sources of ant cuticular microbiota of two Amazonian ant species sharing a common arboreal nest. In preparation

C. Birer, N. Tysklind, L. Zinger*, C. Duplais* (2017) Comparative analysis of DNA extraction methods to study the body surface microbiota of insects : a case study with ant cuticular bacteria Molecular Ecology Resources, 17, e34-e45.


How the biological and chemical compositions of latex impact Amazonian tree evolution ?🌿🌳

Coming soon

Collaborators : Chris Baraloto, Diego Salazar, Oscar Valverde (Florida International University), Frédéric Péruch & Stéphane Carlotti (LPCO, Université de Bordeaux)
Undergraduate student : M1 : Joan Balmot (2016, Université de Montpellier)
Grant : CEBA (2015-2016)

A-M Cortesero, M. Profitt, C. Duplais, F. Viard (2016) Chemical ecology : an integrative and experimental science. In New Advances in Chemical Ecology, Eds : A. G. Bagnères, M. Hossaert-McKey, Coll. ISTE-WILEY. ISBN : 978-1-84821-924-3


Other topic : Medicinal chemistry against malaria 💊💉

The search for safe antimalarial compounds, acting against asexual symptom-responsible stage and sexual transmission-responsible forms of Plasmodium species, is one of the major challenges in malaria elimination programs. So far, among current drugs approved for human use, only primaquine fulfills this objective.
In collaboration with the parasitology unit of the Pasteur Institute of French Guiana, we have successfully settled transmission-blocking biossays based on the inhibition of male gametocytes exflagellation using P. falciparum reference strains and field isolates from French Guiana. We are interested in antimalarial and transmission-blocking activities of safe and inexpensive dyes and additionally we investigate their use as coupling partner in covalent biotherapy strategy.

Collaborators : Lise Musset & Stéphane Pelleau (Institut Pasteur de la Guyane), Eric Legrand, (Pasteur Paris), Jean Popovici (Institut Pasteur du Cambodge), Louis-Jérôme Leba (UMR QualiSud, Université de Guyane)
Undergraduate student :
B.Sc : Giovany Marie-Rose (2016, Université de Guyane)
Grant : Institut Pasteur - ACIP (2012-2014)

Publications
L-J. Leba, J. Popovici, Y. Estevez, S. Pelleau, E. Legrand, L. Musset, C Duplais* (2017)
Antiplasmodial activities of dyes against Plasmodium falciparum asexual and sexual stages : Contrasted uptakes of triarylmethanes Brilliant green, Green S (E142), and Patent Blue V (E131) by erythrocytes, International Journal for Parasitology : Drugs and Drug Resistance, 7, 314-320.
See video abstract here

L-J. Leba, L. Musset, S. Pelleau, Y. Estevez, C. Birer, S. Briolant, B. Witkowski, D. Menard, M. Delves, E. Legrand, C Duplais, J. Popovici* (2015). Use of Plasmodium falciparum culture-adapted field isolates for in vitro exflagellation-blocking assay. Malaria Journal 14, 214

People

Current


PhD. students :
Anaïs Chanson. Co-supervised with Corrie Moreau
Claudiane Flora. Co-supervised with Yannick Estevez, Nadine Amusant and Marie France Thevenon-Brillard

Former


Postdoctoral fellows
Dr. Louis-Jérôme Leba. Now Assistant Professor in plant biology at the University of French Guiana.
Dr. Isabelle Boulogne. Now Assistant Professor in plant biology at the University of Rouen.
Dr. Jean Popovici. Now Researcher at the Pasteur Institut of Cambodia (Malaria Unit-team).

PhD. students
Dr. Caroline Birer. Postdoctoral researcher in Erik Wright lab at the University of Pittsburg.

Undergraduate students
Morissette Deborah (University of French Guiana). Now undergraduate at the University of Lille.
Maeva Gaboriau (University of French Guiana).
Fabrice Cadet (University of French Guiana). Now undergraduate at the University of Lille.
Giovany Marie Rose (University of French Guiana). Now graduate student in the group of Aurélien Blanc at the University of Strasbourg.
Joan Balmot (University of Montpellier).
Gaël Frédéric (University of Strasbourg). Now engineer at the University of French Giuana
Sacha Cataldo (University of French Guiana). Now undergraduate at Polytech Nice Sophia.
Franciscar Bien-Aimé (University of French Guiana).
Marie-Hélène Soba (University of Reims Champagne Ardennes).
Stéphanie Chou Ket Kime (University of French Guiana).
Marie-Claire Izeros (University of French Guiana).
Pierre Freyre (University of French Guiana). Now animal keeper at AppleGate Park Zoo, Merced.
Priscille Steensma (University of French Guiana). Now Ph.D. student in
Fitzpatrick lab at the University of Geneva.

Publications

2018
T. Fu, E. Houël, N. Amusant, D. Touboul, S. Della-Nega, G. Genta-Jouve G. Fisher*, A. Brunelle, C. Duplais*. Biosynthetic investigation of gamma-lactones in Sextonia rubra wood using in situ TOF-SIMS MS/MS imaging to localize and characterize biosynthetic intermediate. In preparation

C. Birer, C. Moreau, N. Tysklind, G. Genta-Jouve, L. Zinger*, C. Duplais*. Disentangling the sources of ant cuticular microbiota of two Amazonian ant species sharing a common arboreal nest. In review

T. Fu, D. Touboul, S. Della-Nega, E. Houël, N. Amusant, C. Duplais, G. Fisher, A. Brunelle. Tandem MS imaging and in situ identification of bioactive wood metabolites in Amazonian tree species Sextonia rubra. Anal. Chem., 90, 7535–7543.

2017
C. Duplais*, Y. Estevez (2017). Tandem biocatalysis unlocks the challenging de novo production of plant natural products. ChemBioChem, 18, 2192-2195.

L-J. Leba, J. Popovici, Y. Estevez, S. Pelleau, E. Legrand, L. Musset, C. Duplais* (2017). Contrasted antiplasmodial activities of triarylmethane analogues Brilliant Green, Green S and Patent Blue V against Plasmodium falciparum asexual and sexual stages. International Journal for Parasitology : drugs and drug resistance, 7, 314-320.

C. Birer, N. Tysklind, L. Zinger*, C. Duplais* (2017). Comparative analysis of DNA extraction protocols to assess cuticular bacterial diversity of ants. Molecular Ecology Resources, 17, e34-e45.

A. E. Fox Ramos, C. Alcover, L. Evanno, A. Maciuk, M. Litaudon, C. Duplais, G. Bernadat, J.-F. Gallard, J.-C. Jullian, E. Mouray, P. Grellier, P. M. Loiseau, S. Pomel, E. Poupon, P. Champy, M. A. Beniddir (2017). Revisiting Previously Investigated Plants : A Molecular Networking-Based Study of Geissospermum leave. J. Nat. Prod., 80, 1007-1014.

R. Duval*, C. Duplais (2017). Fluorescent natural products as probes and tracers in biology. Nat. Prod. Rep., 34,161-193.

2016
J. Bossu, J. Beauchêne, Y. Estevez, C. Duplais*, B. Clair* (2016). New insights on wood dimensional stability influenced by secondary metabolites : the case of a fast-growing tropical species Bagassa guianensis Aubl. PLoS ONE, 11, e0150777.

2015
L-J. Leba, L. Musset, S. Pelleau, Y. Estevez, C. Birer, S. Briolant, B. Witkowski, D. Menard, M. Delves, E. Legrand, C. Duplais*, J. Popovici* (2015). Use of Plasmodium falciparum culture-adapted field isolates for in vitro exflagellation-blocking assay. Malaria Journal, 14, 214.

K. Cottet, Y. Fromentin, M. Kritsanida, R. Grougnet, G. Odonne, C. Duplais, S. Michel, M.-C. Lallemand (2015). Isolation of Guttiferones from renewable parts of Symphonia globulifera by centrifugal partition chromatography Comparative. Planta Med., 81, 1606.

2014
K. Cottet, G. Genta-Jouve, Y. Fromentin, G. Odonne, C. Duplais, O. Laprevote, S. Michel, M.-C. Lallemand (2014). Comparative LC-MS-based metabolite profiling of the ancient tropical rainforest tree Symphonia globulifera. Phytochemistry, 108, 102.

2013
T. M. Casella, V. Eparvier, H. Mandavad, A. Bendelac, G. Odonne, C. Duplais, L. S. Espindola, D. Stien (2013). Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes : Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402. Phytochemistry, 96, 370.

2012
B. H. Lipshutz, B. R. Taft, A. R. Abela, S. Ghorai, A. Krasovskiy, C. Duplais (2012). Catalysis in the Service of Green Chemistry : Nobel Prize-Winning Palladium-Catalyzed Cross-Couplings, Run in Water at Room Temperature. Platinium Metals Rev., 56, 64.

2011
C. Duplais, A. Krasovskiy, B. H. Lipshutz (2011). Organozinc Chemistry Enabled by Micellar Catalysis. Pd-Catalyzed Cross-Couplings Between Alkyl and Aryl Bromides in Water at Room Temperature. Organometallics, 30, 6090.

B. H. Lipshutz, S. Ghorai, A. R. Abela, R. Moser, T. Nishikata, C. Duplais, A. Krasovskiy, R. D. Gaston, R. C. Gadwood (2011). TPGS-750-M : A Second-Generation Amphiphile for Metal-Catalyzed Cross-Couplings in Water at Room Temperature. J. Org. Chem., 76, 4379.

A. Krasovskiy, I. Thomé, J. Graff, V. Krasovskaya, P. Konopelski, C. Duplais, B. H. Lipshutz, (2011). Cross-Couplings of Alkyl Halides with Heteroaromatic Halides, in Water at Room Temperature. Tetrahedron Lett., 52, 2203.

2010
A. Krasovskiy, C. Duplais, B. H. Lipshutz (2010). Stereoselective Negishi-like Couplings Between Alkenyl and Alkyl Halides in Water at Room Temperature. Org. Lett., 12, 4742.

B. H. Lipshutz, A. R. Abela, Z. V. Boskovic, T. Nishikata, C. Duplais, A. Krasovskiy (2010). Greening Up : Cross-Coupling Chemistry. Top. Catal., 53, 985.

C. Duplais, A. J. Forman, B. A Baker, B. H. Lipshutz (2010). UC Pd. A New Form of Pd/C for Sonogashira Couplings. Chem. Eur. J., 16, 3366.

C. Duplais, A. Krasovskiy, Alina Wattenberg, B. H. Lipshutz (2010). Cross-Couplings Between Benzylic and Aryl Halides ‘‘on Water.’’ Synthesis of Diarylmethanes. Chem. Commun., 562.

2009
A. Krasovskiy, C. Duplais, B. H. Lipshutz (2009). Zn-Mediated, Pd-Catalyzed Cross-Couplings in Water at Room Temperature Without Prior Formation of Organozinc reagents. J. Am. Chem. Soc., 131, 15592.

G. Cahiez, C. Duplais, J. Buendia (2009). The Chemistry of Organomanganese Compounds. Chem. Rev., 109, 1434.

G. Cahiez, C. Duplais, J. Buendia (2009). Manganese-Catalyzed Oxydative Cross-Couplings of Grignard Reagents Using Oxygen as Oxidant. Angew. Chem. Int. Ed., 48, 6731.

G. Cahiez, C. Chaboche, C. Duplais, A. Moyeux (2009). A New Efficient Catalytic System for the Chemoselective Cobalt-Catalyzed Cross-Coupling of Aryl Grignard Reagents with Primary and Secondary Alkyl Bromides. Org. Lett., 11, 277.

2008
G. Cahiez, C. Chaboche, C. Duplais, A. Gulianni, A. Moyeux (2008) Cobalt-Catalyzed Cross Coupling Reaction Between Functionnalized Primary and Secondary Alkyl Halides and Aliphatic Grignard Reagents. Adv. Synth. Catal. 350, 1484.

2007
G. Cahiez, A. Moyeux, J. Buendia, C. Duplais (2007). Manganese- or Iron-Catalyzed Homocoupling of Grignard Reagents Using Atmospheric Oxygen as an Oxidant. J. Am. Chem. Soc., 129, 13788.

G. Cahiez, C. Duplais, A. Moyeux (2007). Iron-Catalyzed Alkylation of Alkenyl Grignard Reagents. Org. Lett., 9, 3253.

G. Cahiez, V. Habiak, C. Duplais, A. Moyeux (2007). Iron-Catalyzed Alkylations of Aromatic Grignard Reagents. Angew. Chem. Int. Ed., 46, 4364.

2004
C. Duplais, F. Bures, I. Sapountzis, T. J. Korn, G. Cahiez, P. Knochel (2004). An Efficient Synthesis of Diaryl Ketones by Iron-Catalyzed Arylation of Aroyl Cyanides. Angew. Chem. Int. Ed., 43, 2968.

CV

Positions
Oct. 2011 - present
CNRS Chargé de Recherche (=Research scientist/Group leader/Associate Professor) at EcoFoG, Cayenne, France.
Scientific affiliate at the Field Museum of Chicago. Corrie Moreau Lab
Elected member of the board of directors of the University of French Guiana (2015-2018)
Member of the scientific council of Labex CEBA
2011 CNRS job applications :
N°16/05, rank : 1 in natural products, chemical ecology
N°12/03, rank : 1 in organic chemistry, catalysis

2011
Postdoctoral researcher, University of Paris XIII, France
Department of Chemistry, PI : Gérard Cahiez (CNRS).
2008 - 2011
Postdoctoral researcher, University of California, Santa Barbara, USA
Department of Chemistry and Biochemistry, PI : Bruce Lipshutz.

Education
2016
HDR (French Habilitation) – University of French Guiana (France)
Medicinal chemistry against malaria and chemical ecology in French Guiana.
2004 - 2008
Ph.D. in organic chemistry – University of Cergy-Pontoise (France)
Manganese- and iron-catalyzed cross-coupling reactions and preparation of functionalized organomanganese compounds. Advisor : Gérard Cahiez, (CNRS).
2003 - 2004
M.Sc. in Fine organic chemistry and total synthesis – University of Cergy-Pontoise (France)
Master’s thesis project on iron catalysis. Advisors : Gérard Cahiez (CNRS) and Paul Knochel (LMU, Munich)
2001 - 2004
Engineer school in organic and inorganic chemistry (ESCOM, Cergy-Pontoise, France)

News

2018

July 13
We are thrilled to announce that our JCJC ANR project has been accepted for funding ! Project AMAZYME : Diversity and evolution of oxidosqualene
cyclases and prenyltransferases in the latex of Amazonian tree species

March 12-17
So excited to collect ants in the Nouragues CNRS Field Station with Corrie Moreau, Anaïs Chanson, Peter Flynn and Axel Touchard !

February 29
Great time showing Anaïs for her first time the amazing Paracou Cirad Experimental Station. Great sampling of Lauraceae and Apocynaceae trees :)

January 27
What’s the connection between candy food dyes 🍭 and malaria research 💊 ?
Find out in this video abstract of our paper made by @InMotionScience
https://www.youtube.com/watch?v=vzFDZu528aQ

January 21-24
Went with Anaïs Chanson to a fantastic Keystone conference Natural Products and Synthetic Biology organized by Jon Clardy, Yi Tang and Sean Brady in Olympia Valley, CA.
http://www.keystonesymposia.org/18J1

January
Apply Now : #AntCourse 2018 in French Guiana : no tuition !. Apply by April 1 http://antcourse.org

2017

September 21
Congrats to Anaïs Chanson who is the recipient of a PhD fellowship from the University of French Guiana. Her thesis, co-surpervised by Christophe Duplais and Corrie Moreau, will focus on the bacterial natural products of ants in French Giuana by studying factors that impact the diversity of the biosynthetic genes that produce cyclodipeptides and non-ribosomal peptides.

September 20
Our Highlight article on two amazing papers in biosynthesis : (1) A. Osbourn and collaborators : PNAS 2017, 114, E6005-E6014 & (2) S. O’Connor and collaborators : Nat. Commun. 2017, 8, 316 is online
C. Duplais*, Y. Estevez (2017) Tandem biocatalysis unlocks the challenging de novo production of plant natural products. ChemBioChem, Early view.
The paper is dedicated to Michel Rohmer.

August 2
Our article Antiplasmodial activities of dyes against Plasmodium falciparum asexual and sexual stages : Contrasted uptakes of triarylmethanes Brilliant green, Green S (E142), and Patent Blue V (E131) by erythrocytes is online International Journal for Parasitology : Drugs and Drug Resistance
L.-J. Leba, J. Popovici, Y. Estevez, S. Pelleau, E. Legrand, L. Musset, C. Duplais*

July 22
Update on my marital status, married the most amazing woman Corrie Moreau

May 11
The first paper of Caroline is online in Molecular Ecology Resources. Congrats Caro !!
C. Birer, N. Tysklind, L. Zinger*, C. Duplais*. Comparative analysis of DNA extraction methods to study the body surface microbiota of insects : a case study with ant cuticular bacteria. Mol. Ecol. Res. Early Views.

April 6
Congratulations to Caroline Birer for successfully defending her amazing and impressive Ph.D work !! Thesis title : Bacterial microbiota of ant’s cuticle in French Guiana : antibiotic activities and community ecology.
Thesis committee members : Jean-Luc Wolfender (University of Geneva), Jérôme Chave (CNRS, UMR EDB-University of Toulouse), Heidy Schimann (INRA, UMR EcoFoG), Grégory Genta-Jouve (UME COMETE-University Paris Descartes)
+ Co-PI : Bruno Figadère (CNRS, UMR BioCIS-University Paris Saclay), Lucie Zinger (ENS), Niklas Tysklind (INRA, UMR EcoFoG), Christophe Duplais (CNRS, UMR EcoFoG)

March 13
Collaborative work just published in Journal of Natural Products by Pierre Champy* & Mehdi A. Beniddir* (UMR BioCIS, Université Paris Saclay)
A. E. Fox Ramos, C. Alcover, L. Evanno, A. Maciuk, M. Litaudon, C. Duplais, G. Bernadat, J.-F. Gallard, J.-C. Jullian, E. Mouray, P. Grellier, P. M. Loiseau, S. Pomel, E. Poupon, P. Champy, M. A. Beniddir (2017). Revisiting Previously Investigated Plants : A Molecular Networking-Based Study of Geissospermum leave J. Nat. Prod. 80 (4), pp 1007–1014

March 1
You want to apply for a Ph.D co-supervised by Christophe Duplais & Corrie Moreau ? Interested in Evolution/Molecular Biology/Chemical Biology ? Interested in Ants/Bacteria/Biosynthetic Gene Clusters/Nonribosomal Peptides/Dicyclopeptides ? Please email me NOW

January 28
Check out our review with my colleague Romain Duval (IRD, UMR MERIT-Paris Descartes) just published in Natural Product Reports
R. Duval, C. Duplais (2017). Fluorescent natural products as tracers and probes in biology. Nat. Prod. Rep, 34:161-193.
AND congrats to Romain who made the beautiful Inside Front Cover

AgendaTous les événements

septembre 2018 :

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août 2018 | octobre 2018

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