Croton

Topic

Metabolomic analyses of Croton extracts from French Guiana for the discovery of new antimalarial molecules

Funding

DRRT, 2013.

PI

Emeline Houël.

Scientific partners

  • USR 3456 - CNRS-Guyane
  • ICSN CNRS UPR2301
  • Institut Pasteur de la Guyane

Presentation of the project

Many Croton species are used throughout the world (Africa, Central and South America, Asia) as a traditional remedy against malaria. In vitro and in vivo bioassays highlighted interesting antiplasmodial activities for some extracts and molecules originating from these species. Even if to our knowledge Croton species are not used by the population of French Guiana as a treatment for fever or malaria, these previous results show that it would be interesting to evaluate the antimalarial potential of the species of French Guiana. Between 5 and 10 species of Croton will be harvested, the different plant parts separated and submitted to extraction. The antiplasmodial activity (Plasmodium falciparum) of the obtained extracts will then be evaluated in vitro. To broaden the spectrum of this work, a metabolomic study of the molecules produced by these plants will be performed on all extracts obtained. Our aim is to establish a “mapping” of the secondary metabolites present in Croton extracts, and to correlate chemical composition and biological activity. These data should also enable us to provide new information in terms of chemotaxonomy of the genus Croton. They will also help targeting the most interesting molecules in terms of biological activity in order to optimize the isolation and identification of the active compounds.

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